Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

Abstract In Parkinson’s disease, pathogenic factors such as the intraneuronal accumulation of the protein α-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtypes of neurons in the brain. Here, we app...

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Bibliographic Details
Main Authors: Sofia Spataro, Bohumil Maco, Stéphane Escrig, Louise Jensen, Lubos Polerecky, Graham Knott, Anders Meibom, Bernard L. Schneider
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
Rodent model
Substantia nigra
Alpha-synuclein
Glucose metabolism
NanoSIMS
Online Access:https://doi.org/10.1186/s40478-023-01608-8

Internet

https://doi.org/10.1186/s40478-023-01608-8

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