Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells

The endocannabinoid system (ECS) exerts immunosuppressive effects, which are mostly mediated by cannabinoid receptor 2 (CBR2), whose expression on leukocytes is higher than CBR1, mainly localized in the brain. Targeted CBR2 activation could limit inflammation, avoiding CBR1-related psychoactive effe...

Full description

Bibliographic Details
Main Authors: Antonella Capozzi, Daniela Caissutti, Vincenzo Mattei, Francesca Gado, Stefano Martellucci, Agostina Longo, Serena Recalchi, Valeria Manganelli, Gloria Riitano, Tina Garofalo, Maurizio Sorice, Clementina Manera, Roberta Misasi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
CB2R agonist
CB2R
immunomodulation
anti-inflammatory activity
Online Access:https://www.mdpi.com/1420-3049/27/1/64

Internet

https://www.mdpi.com/1420-3049/27/1/64

Similar Items