Extracellular Heparan 6-<i>O</i>-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies

Extracellular Heparan 6-<i>O</i>-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies

Pan-cancer analysis of TCGA and CPTAC (proteomics) data shows that SULF1 and SULF2 are oncogenic in a number of human malignancies and associated with poor survival outcomes. Our studies document a consistent upregulation of SULF1 and SULF2 in HNSC which is associated with poor survival outcomes. Th...

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Bibliographic Details
Main Authors: Yang Yang, Jaeil Ahn, Nathan J. Edwards, Julius Benicky, Aaron M. Rozeboom, Bruce Davidson, Christina Karamboulas, Kevin C. J. Nixon, Laurie Ailles, Radoslav Goldman
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
heparan sulfate 6-<i>O</i>-endosulfatase
SULF1
SULF2
head and neck squamous cell carcinoma
cancer associated fibroblast
Online Access:https://www.mdpi.com/2072-6694/14/22/5553

Internet

https://www.mdpi.com/2072-6694/14/22/5553

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