Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> Exhibiting Clinically Undetected Colistin Heteroresistance Leads to Treatment Failure in a Murine Model of Infection

Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> Exhibiting Clinically Undetected Colistin Heteroresistance Leads to Treatment Failure in a Murine Model of Infection

ABSTRACT Antibiotic resistance is a growing crisis and a grave threat to human health. It is projected that antibiotic-resistant infections will lead to 10 million annual deaths worldwide by the year 2050. Among the most significant threats are carbapenem-resistant Enterobacteriaceae (CRE), includin...

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Bibliographic Details
Main Authors: Victor I. Band, Sarah W. Satola, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, David S. Weiss
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
Klebsiella
antibiotic resistance
clonal heteroresistance
colistin
heteroresistance
Online Access:https://journals.asm.org/doi/10.1128/mBio.02448-17

Internet

https://journals.asm.org/doi/10.1128/mBio.02448-17

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