Mechanisms Underlying the Exquisite Sensitivity of <named-content content-type="genus-species">Candida albicans</named-content> to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes

Mechanisms Underlying the Exquisite Sensitivity of <named-content content-type="genus-species">Candida albicans</named-content> to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes

ABSTRACT Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus Candida albicans. Yet, C. albicans is resistant to these stresses in vitro. Therefore, what accounts for the potent antifungal activity of neutrophils? We show that simulta...

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Bibliographic Details
Main Authors: Despoina Kaloriti, Mette Jacobsen, Zhikang Yin, Miranda Patterson, Anna Tillmann, Deborah A. Smith, Emily Cook, Tao You, Melissa J. Grimm, Iryna Bohovych, Celso Grebogi, Brahm H. Segal, Neil A. R. Gow, Ken Haynes, Janet Quinn, Alistair J. P. Brown
Format: Article
Language:English
Published: American Society for Microbiology 2014-08-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01334-14

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https://journals.asm.org/doi/10.1128/mBio.01334-14

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