Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells

Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells

Tetradecyl 2,3-dihydroxybenzoate (ABG-001) is a lead compound derived from gentisides with a remarkable neuritogenic activity. However, the target of ABG-001 is yet to be defined to date. In this study, the potential target of ABG-001 was investigated via an activity-based protein profiling (ABPP) a...

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Bibliographic Details
Main Authors: Lihong Cheng, Yanhui Wang, Lan Xiang, Jianhua Qi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
neurodegenerative disease
Alzheimer’s disease
ABPP
target identification
PC12 cells
Online Access:https://www.mdpi.com/2227-9059/9/10/1483

Internet

https://www.mdpi.com/2227-9059/9/10/1483

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