Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

Cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson’s disease patients. Ergothioneine (ET), a natural dietary compound, has been shown to have cytoprotective functions, but neuroprotective action...

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Bibliographic Details
Main Authors: Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Lucrecia Chen, Yang-Kai Ng, Crystal Jing-Jing Yeo, Barry Halliwell, Wei-Yi Ong
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Antioxidants
Subjects:
neurodegeneration
ergothioneine
mitochondrial dysfunction
6-OHDA
Parkinson’s disease
Online Access:https://www.mdpi.com/2076-3921/13/6/693

Internet

https://www.mdpi.com/2076-3921/13/6/693

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