Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human

Abstract A demonstration is provided on how algorithmic asymptotic analysis of multi-scale pharmacokinetics (PK) systems can provide (1) system level understanding and (2) predictions on the response of the model when parameters vary. Being algorithmic, this type of analysis is not hindered by the s...

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Bibliographic Details
Main Authors: Dimitris G. Patsatzis, Shengjia Wu, Dhaval K. Shah, Dimitris A. Goussis
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09846-x