Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy

Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy

IntroductionThe Fc region of monoclonal antibodies (mAbs) interacts with the CD16a receptor on natural killer (NK) cells with “low affinity” and “low selectivity”. This low affinity/selectivity interaction results in not only suboptimal anticancer activity but also induction of adverse effects. CD16...

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Bibliographic Details
Main Authors: Shahryar Khoshtinat Nikkhoi, Geng Li, Suha Eleya, Ge Yang, Venu Gopal Vandavasi, Arash Hatefi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
bispecific killer cell engager
BiKE
NK92 cells
CD16a
VHH nanobody
cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039969/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039969/full

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