Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice

Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice

Abstract Despite the initial successes of the Bacillus Calmette-Guerin (BCG) vaccine in children, its efficacy against tuberculosis is highly variable. There is a lack of understanding about how mental conditions influence BCG vaccination. Here, we used the chronic social defeat stress (CSDS) model...

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Bibliographic Details
Main Authors: Rohit Tyagi, Xi Chen, Atika Dhar, Bing Yang, Wei Zhou, Aikebaier Reheman, Yingying Lei, Gang Cao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Animal Diseases
Subjects:
BCG
Vaccine efficacy
Treg
Immune suppression
Depression
Online Access:https://doi.org/10.1186/s44149-023-00102-x

Internet

https://doi.org/10.1186/s44149-023-00102-x

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