Evaluation of two-stage designs of Phase 2 single-arm trials in glioblastoma: a systematic review

Evaluation of two-stage designs of Phase 2 single-arm trials in glioblastoma: a systematic review

Abstract Background Due to economical and ethical reasons, the two-stage designs have been widely used for Phase 2 single-arm trials in oncology because the designs allow us to stop the trial early if the proposed treatment is likely to be ineffective. Nonetheless, none has examined the usage for pu...

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Bibliographic Details
Main Authors: Wonsuk Yoo, Seongho Kim, Michael Garcia, Shwetal Mehta, Nader Sanai
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Medical Research Methodology
Subjects:
Two-stage design of phase 2 single-arm trials in glioblastoma
Evaluation of Simon’s two-stage designs
Systematic review
Optiomal design
Minimax design
Adaptive design
Online Access:https://doi.org/10.1186/s12874-022-01810-7

Internet

https://doi.org/10.1186/s12874-022-01810-7

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