Recessive LAMA5 Variants Associated With Partial Epilepsy and Spasms in Infancy

Recessive LAMA5 Variants Associated With Partial Epilepsy and Spasms in Infancy

ObjectiveThe LAMA5 gene encodes the laminin subunit α5, the most abundant laminin α subunit in the human brain. It forms heterotrimers with the subunit β1/β2 and γ1/γ3 and regulates neurodevelopmental processes. Genes encoding subunits of the laminin heterotrimers containing subunit α5 have been rep...

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Bibliographic Details
Main Authors: Sheng Luo, Zhi-Gang Liu, Juan Wang, Jun-Xia Luo, Xing-Guang Ye, Xin Li, Qiong-Xiang Zhai, Xiao-Rong Liu, Jie Wang, Liang-Di Gao, Fu-Li Liu, Zi-Long Ye, Huan Li, Zai-Fen Gao, Qing-Hui Guo, Bing-Mei Li, Yong-Hong Yi, Wei-Ping Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
LAMA5 gene
infant-onset epilepsy
laminins
trios-based WES
spasms
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.825390/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.825390/full

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