Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma

Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma

Abstract Background Glioblastoma (GBM) has a devastating median survival of only one year. Treatment includes resection, radiation therapy, and temozolomide (TMZ); however, the latter increased median survival by only 2.5 months in the pivotal study. A desperate need remains to find an effective tre...

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Bibliographic Details
Main Authors: Raghupathy Vengoji, Pranita Atri, Muzafar A. Macha, Parthasarathy Seshacharyulu, Naveenkumar Perumal, Kavita Mallya, Yutong Liu, Lynette M. Smith, Satyanarayana Rachagani, Sidharth Mahapatra, Moorthy P. Ponnusamy, Maneesh Jain, Surinder K. Batra, Nicole Shonka
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Connectivity map
In silico analysis
Glioblastoma
HDAC
Blood-brain barrier
Online Access:https://doi.org/10.1186/s13046-021-02135-x

Internet

https://doi.org/10.1186/s13046-021-02135-x

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