SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis

SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis

Background: Inflammatory osteolysis induced by wear particles is the major cause of prosthetic loosening after artificial joint replacement, and its prevention and treatment are difficult worldwide. Our previous study confirmed that sphingosine kinases (SPHKs) are important mediators regulating the...

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Bibliographic Details
Main Authors: Minghui Gu, Baiqi Pan, Weishen Chen, Hai Xu, Xiaoyu Wu, Xuantao Hu, Linli Zheng, Yongyu Ye, Qing Meng, Guoyan Xian, Ziji Zhang, Puyi Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
SPHKs
osteoclast
aseptic prosthetic loosening
periprosthetic osteolysis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.794429/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.794429/full

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