An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia

An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia

Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing preclinical findings to human pathophysiology. Induced pluripotent stem cells (iPSCs) have emerged as a promising solution, offering the potenti...

Full description

Bibliographic Details
Main Authors: Manisha Padmakumar, Steven Biesmans, Jorge S. Valadas, Jan R. Detrez, Gaëlle Gillet, Priscillia Bresler, Marie-Laure Clénet, Irena Kadiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Drug Discovery
Subjects:
iPSC-derived microglia
high-throughput functional screening
phagocytosis assay
lysosomal function
chemotaxis
cytokine release
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2023.1289314/full

Internet

https://www.frontiersin.org/articles/10.3389/fddsv.2023.1289314/full

Similar Items