HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death. We have shown that, in neuroblastoma cells, the bin...

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Bibliographic Details
Main Authors: Chitra Subramanian, Jason A. Jarzembowski, Anthony W. Opipari, Jr, Valerie P. Castle, Roland P.S. Kwok
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800072

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http://www.sciencedirect.com/science/article/pii/S1476558611800072

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