Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods: We conducted a two-sample Mendelian randomization (MR) study to examine...

Full description

Bibliographic Details
Main Authors: Fernanda Morales Berstein, Daniel L McCartney, Ake T Lu, Konstantinos K Tsilidis, Emmanouil Bouras, Philip Haycock, Kimberley Burrows, Amanda I Phipps, Daniel D Buchanan, Iona Cheng, the PRACTICAL consortium, Richard M Martin, George Davey Smith, Caroline L Relton, Steve Horvath, Riccardo E Marioni, Tom G Richardson, Rebecca C Richmond
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
cancer
epigenetic age acceleration
Mendelian randomization
epigenetic clocks
epidemiology
DNA methylation
Online Access:https://elifesciences.org/articles/75374

Internet

https://elifesciences.org/articles/75374

Similar Items