Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis

Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis

Background: To overcome organ shortage during transplantation, interspecies organ generation via blastocyst complementation has been proposed, although not yet in evolutionarily distant species. To establish high levels of chimerism, low chimerism is required early in development, followed by high c...

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Bibliographic Details
Main Authors: Masaki Nagaya, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Kazuhiro Umeyama, Naoaki Mizuno, Toshiya Nishimura, Hiromitsu Nakauchi, Hiroshi Nagashima
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Regenerative Therapy
Subjects:
Insulin-like growth factor 1 receptor
Growth retardation
Pig
Blastocyst complementation techniques
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424001597

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http://www.sciencedirect.com/science/article/pii/S2352320424001597

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