Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ceramide synthesis protects the retina. Sprague-Dawle...

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Detaylı Bibliyografya
Asıl Yazarlar: Hui Chen, Julie-Thu A. Tran, Annette Eckerd, Tuan-Phat Huynh, Michael H. Elliott, Richard S. Brush, Nawajes A. Mandal
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2013-06-01
Seri Bilgileri:Journal of Lipid Research
Konular:
light-induced retinal degeneration
photoreceptor
apoptosis
fingolimod
sphingomyelinase
Online Erişim:http://www.sciencedirect.com/science/article/pii/S0022227520357187

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520357187

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