Structural insights into Charcot–Marie–Tooth disease‐linked mutations in human GDAP1

Structural insights into Charcot–Marie–Tooth disease‐linked mutations in human GDAP1

Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its different subtypes are linked to mutations in dozens of different genes. Mutations in ganglioside‐induced differentiation‐associated protein 1 (GDAP1) cause two types of CMT, demyelinating CMT...

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Bibliographic Details
Main Authors: Aleksi Sutinen, Giang Thi Tuyet Nguyen, Arne Raasakka, Gopinath Muruganandam, Remy Loris, Emil Ylikallio, Henna Tyynismaa, Luca Bartesaghi, Salla Ruskamo, Petri Kursula
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:FEBS Open Bio
Subjects:
Charcot–Marie–Tooth disease
GDAP1
GST superfamily
protein structure
neuropathy
stability
Online Access:https://doi.org/10.1002/2211-5463.13422

Internet

https://doi.org/10.1002/2211-5463.13422

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