Alcohol and e-cigarette damage alveolar-epithelial barrier by activation of P2X7r and provoke brain endothelial injury via extracellular vesicles

Alcohol and e-cigarette damage alveolar-epithelial barrier by activation of P2X7r and provoke brain endothelial injury via extracellular vesicles

Abstract Background Use of nicotine containing products like electronic cigarettes (e-Cig) and alcohol are associated with mitochondrial membrane depolarization, resulting in the extracellular release of ATP, and mitochondrial DNA (mtDNA), mediating inflammatory responses. While nicotine effects on...

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Bibliographic Details
Main Authors: Naveen Mekala, Jayshil Trivedi, Priyanka Bhoj, Namdev Togre, Slava Rom, Uma Sriram, Yuri Persidsky
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Ethanol
Electronic cigarette
Pulmonary alveolar epithelial cells
P2X7r
A804598
Extracellular vesicles
Online Access:https://doi.org/10.1186/s12964-023-01461-1

Internet

https://doi.org/10.1186/s12964-023-01461-1

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