The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis

The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis

Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also homologous to that of cuprizone (CPZ) toxin-induced animal models of demyelination. Aberration of the tryptophan (TRP)...

Full description

Bibliographic Details
Main Authors: Helga Polyák, Zsolt Galla, Nikolett Nánási, Edina Katalin Cseh, Cecília Rajda, Gábor Veres, Eleonóra Spekker, Ágnes Szabó, Péter Klivényi, Masaru Tanaka, László Vécsei
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
multiple sclerosis
PPMS
SPMS
tryptophan
kynurenine
cuprizone
Online Access:https://www.mdpi.com/2227-9059/11/3/945

Internet

https://www.mdpi.com/2227-9059/11/3/945

Similar Items