Effect of Lipid Additives and Drug on the Rheological Properties of Molten Paraffin Wax, Degree of Surface Drug Coating, and Drug Release in Spray-Congealed Microparticles

Paraffin wax is potentially useful for producing spray-congealed drug-loaded microparticles with sustained-release and taste-masking properties. To date, there is little information about the effects of blending lipids with paraffin wax on the melt viscosity. In addition, drug particles may not be e...

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Bibliographic Details
Main Authors: Hongyi Ouyang, Audrey Yi Zheng, Paul Wan Sia Heng, Lai Wah Chan
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/10/3/75