MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward non-neutralizing epitopes. Variable vaccine re...

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Bibliographic Details
Main Authors: Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:Toxins
Subjects:
Bacillus anthracis
protective antigen
lethal factor
vaccine
antibody response
MHC class II
mouse
genetic background
Online Access:http://www.mdpi.com/2072-6651/4/12/1451

Internet

http://www.mdpi.com/2072-6651/4/12/1451

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