Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study)

Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study)

In resource-rich countries, almost all severe hemophilia patients receive prophylactic replacement therapy with factor concentrates to prevent spontaneous bleeding in joints and muscles to decrease the development of arthropathy and risk of long-term disability. Pharmacokinetic (PK)-guided dosing ca...

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Bibliographic Details
Main Authors: Tine M.H.J. Goedhart, Laura H. Bukkems, Michiel Coppens, Karin J. Fijnvandraat, Saskia E.M. Schols, Roger E.G. Schutgens, Jeroen Eikenboom, Floor C.J.I. Heubel-Moenen, Paula F. Ypma, L. Nieuwenhuizen, K. Meijer, Frank W. G. Leebeek, Ron A.A. Mathôt, Marjon H. Cnossen
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-01-01
Series:TH Open
Subjects:
hemophilia
pharmacokinetics
factor viii
factor ix
prophylaxis
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-1760-0105

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/a-1760-0105

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