Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H<sub>2</sub>S to Inorganic and Organic Hydropolysulfides and Thiosulfate

Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H<sub>2</sub>S to Inorganic and Organic Hydropolysulfides and Thiosulfate

Naphthoquinone (1,4-NQ) and its derivatives (NQs, juglone, plumbagin, 2-methoxy-1,4-NQ, and menadione) have a variety of therapeutic applications, many of which are attributed to redox cycling and the production of reactive oxygen species (ROS). We previously demonstrated that NQs also oxidize hydro...

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Bibliographic Details
Main Authors: Kenneth R. Olson, Kasey J. Clear, Yan Gao, Zhilin Ma, Nathaniel M. Cieplik, Alyssa R. Fiume, Dominic J. Gaziano, Stephen M. Kasko, Jennifer Luu, Ella Pfaff, Anthony Travlos, Cecilia Velander, Katherine J. Wilson, Elizabeth D. Edwards, Karl D. Straub, Gang Wu
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
reactive sulfur species
reactive oxygen species
antioxidants
naphthoquinones
naphthoquinone thiol adducts
Online Access:https://www.mdpi.com/1422-0067/24/8/7516

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https://www.mdpi.com/1422-0067/24/8/7516

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