A comparison of DP-TOF Mass Spectroscopy (MS) and Next Generation Sequencing (NGS) methods for detecting molecular mutations in thyroid nodules fine needle aspiration biopsies

A comparison of DP-TOF Mass Spectroscopy (MS) and Next Generation Sequencing (NGS) methods for detecting molecular mutations in thyroid nodules fine needle aspiration biopsies

Mutations in the B-Raf proto-oncogene, serine/threonine kinase (BRAF), have been linked to a variety of solid tumors such as papillary thyroid carcinoma. The purpose of this study was to compare the DP-TOF, a DNA mass spectroscopy (MS) platform, and next-generation sequencing (NGS) methods for detec...

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Bibliographic Details
Main Authors: Xiao-qin Qian, Enock Adjei Agyekum, Ling-ling Zhao, Run-liu Yu, Xiu-ying Li, De-jian Gu, Na Yan, Ming Xu, Yuan Yuan, Yu-guo Wang, Wu Xin-ping, Fei-ju Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
thyroid nodules
BRAF gene
next generation sequencing
mass spectroscopy
fine needle aspiration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.928788/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.928788/full

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