Role of metal ions in the cognitive decline of Down syndrome

Role of metal ions in the cognitive decline of Down syndrome

Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All Down syndrome (DS) individuals suffer from cognitive decline and develop Alzheimer’s disease (AD) by the age of forty. The appearance of enlarged early endosomes, followed by Amyloid β p...

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Bibliographic Details
Main Authors: Nakisa eMalakooti, Melanie ePritchard, Paul eAdlard, David eFinkelstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer Disease
Calcium
Copper
Down Syndrome
Homeostasis
Iron
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00136/full

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