Malic enzymes in cancer: Regulatory mechanisms, functions, and therapeutic implications

Malic enzymes in cancer: Regulatory mechanisms, functions, and therapeutic implications

Malic enzymes (MEs) are metabolic enzymes that catalyze the oxidation of malate to pyruvate and NAD(P)H. While researchers have well established the physiological metabolic roles of MEs in organisms, recent research has revealed a link between MEs and carcinogenesis. This review collates evidence of...

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Bibliographic Details
Main Authors: Huan Wang, Wanlin Cui, Song Yue, Xianglong Zhu, Xiaoyan Li, Lian He, Mingrong Zhang, Yan Yang, Minjie Wei, Huizhe Wu, Shuo Wang
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Redox Biology
Subjects:
Malic enzymes
Cancer
Drug resistance
Cancer therapy
Malic enzyme inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724002519

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http://www.sciencedirect.com/science/article/pii/S2213231724002519

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