Effects of azithromycin on bronchial remodeling in the natural model of severe neutrophilic asthma in horses

Abstract Steroid resistance in asthma has been associated with neutrophilic inflammation and severe manifestations of the disease. Macrolide add-on therapy can improve the quality of life and the exacerbation rate in refractory cases, possibly with greater effectiveness in neutrophilic phenotypes. T...

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Bibliographic Details
Main Authors: Sophie Mainguy-Seers, Roxane Boivin, Sheila Pourali Dogaheh, Francis Beaudry, Pierre Hélie, Alvaro G. Bonilla, James G. Martin, Jean-Pierre Lavoie
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03955-9