Distinct Characteristics and Clinical Outcomes to Predict the Emergence of <i>MET</i> Amplification in Patients with Non-Small Cell Lung Cancer Who Developed Resistance after Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

Distinct Characteristics and Clinical Outcomes to Predict the Emergence of <i>MET</i> Amplification in Patients with Non-Small Cell Lung Cancer Who Developed Resistance after Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

Objectives: Patients with epidermal growth factor receptor (<i>EGFR</i>) mutant non-small cell lung cancer (NSCLC) ultimately acquire resistance to <i>EGFR</i> tyrosine kinase inhibitors (TKIs) during treatment. In 5–22% of these patients, resistance is mediated by aberrant m...

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Bibliographic Details
Main Authors: Beung-Chul Ahn, Ji Hyun Lee, Min Hwan Kim, Kyoung-Ho Pyo, Choong-kun Lee, Sun Min Lim, Hye Ryun Kim, Byoung Chul Cho, Min Hee Hong
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
non-small cell lung cancer
epidermal growth factor receptor
tyrosine kinase inhibitor
<i>MET</i> amplification
Online Access:https://www.mdpi.com/2072-6694/13/12/3096

Internet

https://www.mdpi.com/2072-6694/13/12/3096

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