Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA

Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA

Abstract Bipolar disorder (BD) is a severe psychiatric disorder characterized by repeated conflicting manic and depressive states. In addition to genetic factors, complex gene–environment interactions, which alter the epigenetic status in the brain, contribute to the etiology and pathophysiology of...

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Bibliographic Details
Main Authors: Hiroko Sugawara, Miki Bundo, Takaoki Kasahara, Yutaka Nakachi, Junko Ueda, Mie Kubota-Sakashita, Kazuya Iwamoto, Tadafumi Kato
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Molecular Brain
Subjects:
Bipolar disorder
Schizophrenia
DNA methylation
Neuron
Nonneuron
Mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s13041-021-00894-4

Internet

https://doi.org/10.1186/s13041-021-00894-4

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