Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases

Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases

Type II topoisomerases are essential enzymes that modulate the topological state of DNA supercoiling in all living organisms. These enzymes alter DNA topology by performing double-stranded passage reactions on over- or underwound DNA substrates. This strand passage reaction generates a transient cov...

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Bibliographic Details
Main Authors: Jeffrey Y. Jian, Neil Osheroff
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
DNA topoisomerase
DNA topology
supercoil handedness
type II topoisomerase
DNA relaxation
DNA cleavage
Online Access:https://www.mdpi.com/1422-0067/24/13/11199

Internet

https://www.mdpi.com/1422-0067/24/13/11199

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