SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma

SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma

Abstract Background The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have shown inhibited phagocytosis of macrophages in distinct tumors. However, phagocytosis checkpoints and their therapeutic significance remain largely unknown in intrahepatic cholangiocarcinoma...

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Bibliographic Details
Main Authors: Hui Yang, Meimei Yan, Wei Li, Linping Xu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Translational Medicine
Subjects:
TAMs
Phagocytosis checkpoints
SIRPα
PD1
SIGLEC10
Online Access:https://doi.org/10.1186/s12967-022-03342-6

Internet

https://doi.org/10.1186/s12967-022-03342-6

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