Nanoparticle-Mediated Inhibition of Notch Signaling Promotes Mitochondrial Biogenesis and Reduces Subcutaneous Adipose Tissue Expansion in Pigs

Nanoparticle-Mediated Inhibition of Notch Signaling Promotes Mitochondrial Biogenesis and Reduces Subcutaneous Adipose Tissue Expansion in Pigs

Summary: Inhibition of Notch signaling has been shown to induce white to beige transformation of adipocytes and reduce the risk of obesity in mice. However, it remains unknown whether the metabolic benefits of Notch inhibition are dependent on uncoupling protein 1 (UCP1)-mediated thermogenesis and e...

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Bibliographic Details
Main Authors: Di Huang, Naagarajan Narayanan, Mario A. Cano-Vega, Zhihao Jia, Kolapo M. Ajuwon, Shihuan Kuang, Meng Deng
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Biological Sciences
Physiology
Cellular Physiology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303527

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http://www.sciencedirect.com/science/article/pii/S2589004220303527

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