Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma

Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma

BackgroundRenal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%). 75% of the RCC cases involve conventional clear cell RCC (ccRCC). Approximately, 39% of late-stage patients (stage IV) are treated with chemotherapeutic agents. Phosphatidylinositol-3-kinase (PI3K) and Mitogen-Activ...

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Bibliographic Details
Main Authors: Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Mildred Acevedo-Duncan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Oncology
Subjects:
renal cell carcinoma
ICA-1
BYL719
PKC-ι
PKC-ζ
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1213715/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1213715/full

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