Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Abstract Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal control of gene expression. To overco...

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Bibliographic Details
Main Authors: Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Molecular Brain
Subjects:
ROCK2
Rho kinase
Dendritic spine
Hippocampus
Prefrontal cortex
Amygdala
Online Access:https://doi.org/10.1186/s13041-021-00878-4

Internet

https://doi.org/10.1186/s13041-021-00878-4

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