DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor

DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor

HPV-independent head and neck squamous cell carcinoma (HNSCC) is a common cancer globally. The overall response rate to anti-PD1 checkpoint inhibitors (CPIs) in HNSCC is ~16%. One major factor influencing the effectiveness of CPI is the level of tumor infiltrating T cells (TILs). Converting TILlow t...

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Bibliographic Details
Main Authors: Chuan Wang, Nur Syafinaz Zainal, San Jiun Chai, James Dickie, Chai Phei Gan, Natasha Zulaziz, Bryan Kit Weng Lye, Ruhcha V. Sutavani, Christian H. Ottensmeier, Emma V. King, Mannil Thomas Abraham, Siti Mazlipah binti Ismail, Shin Hin Lau, Thomas George Kallarakkal, Kein Seong Mun, Rosnah binti Zain, Zainal Ariff Abdul Rahman, Gareth J. Thomas, Sok Ching Cheong, Natalia Savelyeva, Kue Peng Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
DNA vaccine
cancer immunotherapy
head and neck cancer
MAGED4B
FJX1
cancer antigens
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763086/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.763086/full

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