Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenylation destabilizes AU-rich element (ARE)-containing...

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Bibliographic Details
Main Authors: Clara Suñer, Annarita Sibilio, Judit Martín, Chiara Lara Castellazzi, Oscar Reina, Ivan Dotu, Adrià Caballé, Elisa Rivas, Vittorio Calderone, Juana Díez, Angel R Nebreda, Raúl Méndez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
mRNA stability
RNA Binding Protein
CPEB
TTP
MAPK
Online Access:https://elifesciences.org/articles/75873

Internet

https://elifesciences.org/articles/75873

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