The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was synthesized as cis-restricted-combretastatin-A-4-analogue and then chemically modified to have improved solubility and a wider therapeutic inde...

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Bibliographic Details
Main Authors: Katia Grillone, Caterina Riillo, Roberta Rocca, Serena Ascrizzi, Virginia Spanò, Francesca Scionti, Nicoletta Polerà, Annalisa Maruca, Marilia Barreca, Giada Juli, Mariamena Arbitrio, Maria Teresa Di Martino, Daniele Caracciolo, Pierosandro Tagliaferri, Stefano Alcaro, Alessandra Montalbano, Paola Barraja, Pierfrancesco Tassone
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
cancer treatment
immunogenic cell death
ICD inducers
MTAs
multiple myeloma
Online Access:https://www.mdpi.com/1422-0067/23/18/10222

Internet

https://www.mdpi.com/1422-0067/23/18/10222

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