Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice

Background: The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of cardiovascular disease. MicroRNAs (miRNAs, miRs) have been shown to regulate various pat...

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Bibliographic Details
Main Authors: Cheng Chen, David Matye, Yifeng Wang, Tiangang Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-12-01
Series:Liver Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568420300416