Polygenic risk scores of lithium response and treatment resistance in major depressive disorder

Abstract Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed to derive a stringent definition of treatment res...

Full description

Bibliographic Details
Main Authors: Ying Xiong, Robert Karlsson, Jie Song, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Evelyn Andersson, Julia Boberg, Cathryn M. Lewis, Patrick F. Sullivan, Mikael Landén, Yi Lu
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02602-3