X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

Abstract Background and aim Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovascular health. In women, X-linked mechanisms such as...

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書目詳細資料
Main Authors: Michele F. Buono, Ernest Diez Benavente, Mark Daniels, Barend M. Mol, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Sander W. van der Laan, Gerard Pasterkamp, Charlotte Onland-Moret, Michal Mokry, Hester M. den Ruijter
格式: Article
語言:English
出版: BMC 2023-07-01
叢編:Biology of Sex Differences
主題:
Atherosclerosis
Sex-differences
XCI skewing
Vascular
Carotid
Peripheral
在線閱讀:https://doi.org/10.1186/s13293-023-00527-6

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https://doi.org/10.1186/s13293-023-00527-6

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