Design, Synthesis and Biological Evaluation of <i>Syn</i> and <i>Anti</i>-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Design, Synthesis and Biological Evaluation of <i>Syn</i> and <i>Anti</i>-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Our investigation includes the synthesis of new naphthalene-bis-triazole-bis-quinolin-2(1H)-ones <b>4a</b>–<b>e</b> and <b>7a</b>–<b>e</b> via Cu-catalyzed [3 + 2] cycloadditions of 4-azidoquinolin-2(1<i>H</i>)-ones <b>3a</b>–&l...

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Bibliographic Details
Main Authors: Essmat M. El-Sheref, Mohamed A. Ameen, Kamal M. El-Shaieb, Fathy F. Abdel-Latif, Asmaa I. Abdel-naser, Alan B. Brown, Stefan Bräse, Hazem M. Fathy, Iqrar Ahmad, Harun Patel, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Asmaa H. Mohamed
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
azide
naphthalene
click
quinolin-2-one
apoptosis
caspases
Online Access:https://www.mdpi.com/1420-3049/27/24/8765

Internet

https://www.mdpi.com/1420-3049/27/24/8765

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