Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer

Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer

Abstract Harnessing the power of immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry by genomic alterations enables tumor cells to escape immune surveillance, leading to therapeutic failure. Uncovering the molecular basis of how tumor mutations...

Full description

Bibliographic Details
Main Authors: Changfa Shu, Jianfeng Li, Jin Rui, Dacheng Fan, Qiankun Niu, Ruiyang Bai, Danielle Cicka, Sean Doyle, Alafate Wahafu, Xi Zheng, Yuhong Du, Andrey A. Ivanov, Deon B. Doxie, Kavita M. Dhodapkar, Jennifer Carlisle, Taofeek Owonikoko, Gabriel Sica, Yuan Liu, Suresh Ramalingam, Madhav. V Dhodapkar, Wei Zhou, Xiulei Mo, Haian Fu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57297-5

Internet

https://doi.org/10.1038/s41467-025-57297-5

Similar Items