Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53‐Dependent Apoptosis

Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53‐Dependent Apoptosis

BackgroundCardiomyocytes differentiated from human pluripotent stem cells can serve as an unexhausted source for a cellular cardiac disease model. Although small molecule–mediated cardiomyocyte differentiation methods have been established, the differentiation efficiency is relatively unsatisfactory...

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Bibliographic Details
Main Authors: Xiao‐Xu Qiu, Yang Liu, Yi‐Fan Zhang, Ya‐Na Guan, Qian‐Qian Jia, Chen Wang, He Liang, Yong‐Qin Li, Huang‐Tian Yang, Yong‐Wen Qin, Shuang Huang, Xian‐Xian Zhao, Qing Jing
Format: Article
Language:English
Published: Wiley 2017-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
apoptosis
cardiac differentiation
human embryonic stem cells
mammalian target of rapamycin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.005295

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.005295

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