Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing

Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing

Abstract Background Detecting trans-ethnic common associated genetic loci can offer important insights into shared genetic components underlying complex diseases/traits across diverse continental populations. However, effective statistical methods for such a goal are currently lacking. Methods By le...

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Bibliographic Details
Main Authors: Jiahao Qiao, Zhonghe Shao, Yuxuan Wu, Ping Zeng, Ting Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Translational Medicine
Subjects:
Trans-ethnic genetic overlap
Composite null hypothesis testing
Summary statistics
Gene-centric association analysis
CONTO
Joint significance test
Online Access:https://doi.org/10.1186/s12967-022-03637-8

Internet

https://doi.org/10.1186/s12967-022-03637-8

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