NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ salvage and lactate metabolism. Using lung t...

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Bibliographic Details
Main Authors: Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40545-x

Internet

https://doi.org/10.1038/s41467-023-40545-x

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