Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10%...

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Bibliographic Details
Main Authors: Poovizhi Ponnammal, Parijat Kanaujia, Yin Yani, Wai Kiong Ng, Reginald B. H. Tan
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Pharmaceutics
Subjects:
melt extrusion
amorphous solid dispersion
dissolution enhancement
tacrolimus
orally-disintegrating tablets
Online Access:http://www.mdpi.com/1999-4923/10/1/35

Internet

http://www.mdpi.com/1999-4923/10/1/35

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