Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway

Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway

Matrix metalloproteinase-9 is upregulated in inflammatory bowel disease. Barbiturate nitrate hybrid compounds have been designed to inhibit MMP secretion and enzyme activity. In this study, we investigated the mechanism of action of barbiturate-nitrate hybrid compounds and their component parts usin...

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Bibliographic Details
Main Authors: Shane O’Sullivan, Jun Wang, Marek W. Radomski, John F. Gilmer, Carlos Medina
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomolecules
Subjects:
inflammatory bowel disease
inflammation
NO
MMP-9
cGMP
Caco-2
Online Access:https://www.mdpi.com/2218-273X/10/5/808

Internet

https://www.mdpi.com/2218-273X/10/5/808

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